Histoplasmosis is a progressive granulomatous disease caused by intracellular dimorphic fungus Histoplasma capsulatum. The fungus present in the soil infects through inhalational route and can manifest as any of the three main types-acute primary pulmonary type, chronic cavitatory or progressive disseminated. In disseminated histopasmosis (DH), the fungus is detected from more than one location in the body. This is the rarest form of all three types and is usually present in immunocompromised individuals. We report the case of a 27-year-old immunocompetent patient who presented with prolonged fever, weight loss, pain abdomen and skin lesions. She was found to have hepatosplenomegaly and pancytopenia. Biopsy from skin lesions and bone marrow stained positive for H. capsulatum sp. She was treated with amphotericin B for 28 days, followed by oral Itraconazole for 6 months, leading to complete resolution of the disease. This case is interesting due to the presence of disseminated histoplasmosis in an immunocompetent host with prominent skin lesions.

Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia due to defects in insulin secretion, action or both. Several different types of DM exist and are caused by a complex interaction of genetics, environmental factors and life style choices. Aims and Objectives: To study the prevalence and morphological pattern of peripheral arterial lesions in patients with DM by duplex color doppler ultrasonography and to correlate the findings with the various risk factors and variables. Materials and Methods: A complete history and physical examination including examination of the lower limbs with respect to peripheral arterial disease, basic routine blood and urine laboratory investigation, assessment of peripheral arterial disease by doppler ultrasonography of lower limb arteries and assessment of diabetic complications were carried out on 50 cases of type 2 DM of more than 5 years duration and 25 controls of non-diabetic population. Type 1 DM and type 2 DM patients with duration of diabetes less than 5 years were excluded from the study as were the patients of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT).

Takayasu arteritis is an idiopathic, autoimmune, large vessel vasculitis, mainly affecting the young adults. Its exact etiopathogenesis is not known and it has varied clinical presentations. Acute stroke as initial presentation of Takayasu arteritis is uncommonly reported. Herein we present a case of a 24-year-old female who came to our hospital emergency with sudden onset of weakness of left half of the body of one-day duration. Takayasu arteritis complicated with acute ischemic stroke was diagnosed on the basis of CT angiography findings. The patient was managed accordingly and discharged in a stable condition. Relevant literature is also reviewed. Although considered to be a rare disease, Takayasu arteritis is not infrequent. A high index of suspicion is required for early diagnosis, so as to reduce the significant morbidity associated with the disease.